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Thioctic Acid

Product name:Thioctic Acid
CAS No.:1077-28-7
EINECS: 200-534-6
MF: C8H14O2S2
MW: 206.326
Purity: 99.0-101.0%
Melting point: 58-63℃
Boiling point: 362.5°C at 760 mmHg
Appearance:Light Yellow Powder
Certification: ISO, KOSHER, Halal, Organic;
Bulk stock in USA Warehouse

What is Thioctic Acid?

Thioctic acid, or α-lipoic acid, is used for its antioxidant effects in the treatment of diabetic neuropathy. It has been tried in the treatment of liver dysfunction and in subacute necrotising encephalopathy. Thioctic acid and its reduced metabolite form a redox couple and may scavenge a wide range of reactive oxygen species.

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Specification:

Product nameThioctic AcidGradeFeed grade
AppearanceYellow crystalline powderTest MethodHPLC

ITEMSSPECIFICATIONMETHOD
AppearanceYellow powderOrganoleptic
IdentificationMeets the requirementsHPLC
Melting point60-62℃USP
Specific rotation-1.0°to +1.0°USP
Loss on drying≤0.20%USP
Residue on ignition≤0.10%USP
Heavy metals≤10ppmUSP
Lead≤3ppmUSP
Cadmium≤1ppmUSP
Mercury≤0.1ppmUSP
Chromatographic purity
Single impurity≤0.10%HPLC
Total impurities≤2.0%HPLC
Residual Solvent By GC
Cyclohexane≤1000ppmGC
Ethyl acetate≤250ppmGC
Toluene≤20ppmGC
Microbiology
Total Plate Counts≤1000cfu/gUSP
Moulds and Yeasts≤100cfu/gUSP
E.Coli and SalmonellaAbsence/gUSP
Staphylococcus aureusAbsence/gUSP
Particle size100% through 20 meshUSP
Assay98.5%-101.0%HPLC


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Uses

1. Under normal fat levels, lipoic acid can promote zebrafish’s nutritional metabolism. Under high fat levels, lipoic acid can reduce lipid accumulation caused by high fat, inhibit protein catabolism, and increase the protein content of whole fish. The experiment was divided into two stages.First, 540 male zebrafish (0.17g) were randomly divided into two groups, each with 6 tanks, fed with normal (CT, fat level 5%) and high fat (HL, fat level). 10%) The diet was for 6 weeks, and 9 fish were sampled in each tank. Then, three tanks of test fish were randomly selected from the two groups and fed diets containing 1000 mg kg~(-1) lipoic acid (CT+LA and HL+LA) for 6 weeks. The results showed that lipoic acid can increase the protein content of whole fish and down-regulate the mRNA levels of muscle protein catabolism-related genes under high-fat diets (P0.05). High-fat diets significantly increase the lipid content of whole fish and up-regulate the expression levels of genes related to gluconeogenesis and lipid synthesis. Adding lipoic acid diets can alleviate these effects and reduce the lipid content and expression of genes related to lipid synthesis in whole fish. Level, and up-regulate the mRNA level of lipid catabolism-related genes (P0.05). In addition, the addition of lipoic acid to high-fat diets significantly increased the number of mitochondria in the liver, and up-regulated the expression levels of mitochondrial synthesis and respiratory chain-related genes (P0.05).

2. Thioctic acid promotes lipid catabolism of grass carp fat cells and reduces the triglyceride content of fat cells. The mature adipocytes of grass carp were incubated with 0, 50, 200 μM lipoic acid for 6 hours, and the lipid metabolism related indexes of adipocytes were detected. The results showed that 200μM lipoic acid significantly reduced the triglyceride content of grass carp adipocytes, and increased the release of glycerol and non-esterified fatty acids from adipocytes at the same time. The mRNA expression level of lipolysis-related genes (HSL, PPARα, CPT1, CD36) in adipocytes in the 200μM lipoic acid group was significantly higher than that in the control group (P0.05).

3. Adding acid thioctic to diets with different fat levels reduces the lipid accumulation of grass carp, and at the same time reduces food intake by regulating the gene expression of peripheral appetite factors, thereby reducing growth performance. In this experiment, 1200 mg kg~(-1) lipoic acid was added to diets with 4% and 8% fat levels to feed grass carp juveniles for 8 weeks. The growth, food intake, conventional composition and peripheral appetite factor gene expression were analyzed and detected. The results showed that supplementation of lipoic acid diets significantly reduced the weight, weight gain and food intake of juvenile grass carp, and high-fat diets would reduce food intake (P0.05).

DOSAGE

Gradualaction Alpha Lipoic acid is intended for dogs and cats and is administered mixed with feed at a dose of 1 capsule every 10 kg of body weight, twice a day.

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The Thioctic Acid Supplier

Green agri enjoys long term relationships with our clients because we focus on customer service and providing great products. If you are interested in our products, we are flexible with the customization of orders to suit your specific need and our quick lead time on orders guarantees you’ll have great tasting our products on-time.

We also focus on value-added services. We are available for service questions and information to support your business.

Why Choose Thioctic Acid?

Green agri specialize in acid thioctic for several years, we supply products with competitive price, and our product is of the highest quality and undergoes strict, independent testing to ensure that it is safe for consumption around the world.

Where to buy Thioctic Acid?

Just send email to info@greenagribio.com, or submit your requirement in bottom form, we are of service at any time!

 

Why choose us?

  • Our factory has the capacity to produce large quantities of intermediates to meet any demand.
  • We have advanced production equipment and strong technical strength, so our Thioctic Acid has excellent cost performance, which has become a weapon for us to fight the market.
  • If you are looking for intermediates that are of a high quality, then look no further than our factory.
  • The company always adheres to the principle of “survive by quality and promote development by science and technology”, adopts a modern process layout, implements scientific management, and has a perfect quality system. Since its establishment, the company has been adhering to the business philosophy of “satisfying customer needs first, seeking development with quality and service”, and has become a supplier of many well-known large enterprises.
  • We take pride in our ability to deliver high-quality intermediates that meet or exceed our customers’ expectations.
  • We will provide advanced product technology, optimal solutions, the most flexible logistics services and the most competitive product cost for terminal customers.
  • We use only the best materials and processes to manufacture intermediates that meet the highest quality standards.
  • Our company always regards quality as life, strengthens product quality, takes serving customers as the goal, pays attention to management, and wins the trust of customers at home and abroad with high quality products.
  • Our commitment to quality and customer service sets us apart from our competitors.
  • We have a professional product development and design team to ensure that it can be customized according to the process needs of our customers.

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