Astragalus Polysaccharide

What is Astragalus Polysaccharide?

A. membranaceus is one of the most popular herbal medicines worldwide. In China, Astragalus Polysaccharide is known as “Huangqi.” In traditional Chinese medicine, it is used as medicine and food to invigorate the spleen and replenish qi. Astragalus root extract(APS) is a type of water-soluble heteropolysaccharide with bioactive effects, which is extracted from the stems or dried roots of Astragalus Polysaccharide .

The components are complex and diverse, and polymeric carbohydrates are mainly linked by α-type glycosidic bonds between the monosaccharides (Li C. et al., 2019). APS is the most important natural active component in A. membranaceus and exerts multiple pharmacological effects (Li S.S. et al., 2019).

Analysis:

Astragalus Polysaccharide Benefits:

Benefit 1: Immunomodulatory activity of astragalus polysaccharides

Astragalus polysaccharide extract can significantly enhance the non-specific immune function and humoral immune function, significantly enhance the phagocytosis of mouse macrophages, promote the formation of serum hemolysin, improve the hemolysis function of plaque-forming cells and obvious carbon ion clearance and significantly increase spleen weight.

Benefit 2: Astragalus polysaccharides have obvious inhibitory effects on various experimental tumor oils

Animal experiments have shown that astragalus root extract powder have similar anti-tumor effects to IL-2/LAK, and can significantly enhance the anti-tumor effects of IL-2/LAK. It can improve the low immune function caused by tumors in the body, promote the activation of immune cells to release endogenous factors, prevent peroxidation and thus cause killing and inhibition of tumor cells, and is used to treat chicken Marek’s disease.

Benefit 3: Impact on wound infection

The pharmacological experiments of astragalus polysaccharide extract on experimental mouse wounds showed that it can significantly enhance the phagocytosis luminescence intensity of macrophages, inhibit the release of PCE2, and further promote the release of TNF. The combination of immune activator astragalus polysaccharide and cyclooxygenase inhibitor ibuprofen not only enhanced the phagocytosis luminescence intensity of macrophages, but also significantly inhibited the secretion of PGE2 and TNF IL-1. It can be seen that the combination of immune stimulators and cyclooxygenase inhibitors is expected to become a new drug therapy for wound infection.

Benefit 4: Protective effect

Studies have found that astragalus polysaccharides have obvious protective effects on experimental liver injury, can significantly resist the serum alanine aminotransferase in mice caused by carbon tetrachloride and paracetamol, and have obvious protective effects on the pathological changes in mice caused by the two.

Benefit 5: Regulatory effect on blood sugar

APs have a bidirectional regulatory effect. It can significantly reduce the blood sugar of mice with glucose load, and it can also significantly resist the response of mice with elevated blood sugar caused by adrenaline, and it can also significantly resist the experimental hypoglycemia of mice caused by phenformin. However, it has no significant effect on insulin-induced hypoglycemia.

Benefit 6: Astragalus polysaccharide has antiviral effect

It is an interferon inducer, and its antiviral principle: stimulate the function of macrophages and T cells, increase the number of E-ring-forming cells, induce cytokines, promote the induction of interleukins, and make animals produce endogenous Sexual interferon, so as to achieve the purpose of anti-virus, for the treatment of piglet circovirus disease, chicken infectious bursal disease, influenza virus sexually transmitted diseases. Astragalus root extract powder can prevent colds and reduce the incidence by more than 50%, and the combined application of Astragalus and interferon can reduce the incidence by more than 70%.

Benefit 7: Astragalus polysaccharide has anti-bacterial effect

The mechanism of antibacterial action is multi-faceted. On the one hand, the drug directly inhibits and detoxifies the fine powder and its toxic products; . It has antibacterial effects on Shigella dysenteriae, Bacillus anthracis, Streptococcus pneumoniae, Streptococcus aureus, Escherichia coli and Salmonella.

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